Yersiniabactin Siderophore of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli Is Involved in Autophagy Activation in Host Cells
نویسندگان
چکیده
منابع مشابه
Comparative genomics of Crohn's disease-associated adherent-invasive Escherichia coli.
OBJECTIVE Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular property common to the AIEC phenotype. DESIGN 41 B2 phylogroup E. coli strains we...
متن کاملActivation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection
The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). Upon AIEC infection, autophagy is induced in host cells to restrain bacterial intracellular replication. The underlying mechanism, however, remains unknown. Here, we investigated the role of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway in the autophagic response to AIEC infection. We showed...
متن کاملpathway is involved in biofilm formation by Crohn ’ s disease - associated 1 adherent - invasive Escherichia coli 2 3
σ pathway is involved in biofilm formation by Crohn’s disease-associated 1 adherent-invasive Escherichia coli 2 3 Benoit Chassaing and Arlette Darfeuille-Michaud 4 5 1 Clermont Université, UMR 1071 Inserm/Université Auvergne, Clermont-Ferrand 6 63000, France 7 2 INRA USC 2018, Clermont-Ferrand 63000, France 8 3 Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France 9 10 11 Running tit...
متن کاملUnderstanding Host-Adherent-Invasive Escherichia coli Interaction in Crohn's Disease: Opening Up New Therapeutic Strategies
A trillion of microorganisms colonize the mammalian intestine. Most of them have coevolved with the host in a symbiotic relationship and some of them have developed strategies to promote their replication in the presence of competing microbiota. Recent evidence suggests that perturbation of the microbial community favors the emergence of opportunistic pathogens, in particular adherent-invasive ...
متن کاملInvestigation of adherent-invasive E. coli in patients with Crohn\'s disease
Background: Crohn's disease and Ulcerative colitis are known as inflammatory bowel disease with high morbidity which are as a result of increasing immune responses to intestinal microbiota in genetically susceptible individuals. The association of adherent invasive Escherichia coli with Crohn's disease in human has been discussed for decades. The principal aim of this study was to assess the re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22073512